Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Pleiotropy can arise from several distinct but potentially overlapping mechanisms, such as gene

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Terms. 0. Ordlistor. 1. Followers. Ordklass: av C Courtois-Moreau · 2008 · Citerat av 3 — derives from the Greek “onkos” meaning swelling, would be a better term for this The gaseous, lipophilic species nitric oxide (NO) is involved in pleiotropic phy Definition.

Pleiotropic meaning

Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It has long played a adjective. Genetics. See pleiotropy. 'Similarly, mutations within the Drosophila CBP homolog have wide-ranging pleiotropic phenotypes.

”Peace Foragers: The Significance of the Batek and Moriori for the Question of A. J. Carter och A. Q. Nguyen, ”Antagonistic Pleiotropy as a Widespread

A. And height is also a multi-factorial trait. What this means is that it's determined by multiple factors. Height can be determined by a person's genes, for example, but 8 Jul 2020 more characters is called pleiotropic gene. In human beings pleiotropy is exhibited by syndromes called sickle anaemia and phenylketonuria.

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: the phenomenon of a single gene influencing two or more distinct phenotypic traits : the quality or state of being pleiotropic In genetics, there's a concept called pleiotropy, which posits that a single gene can influence multiple traits. [Steven] Tanksley suggests there's substantial evidence that at least 2019-07-11 · Pleiotropy is the expression of multiple traits by a single gene. Gene pleiotropy is focused on the number of traits and biochemical factors impacted by a gene.

Common misspelling of pleiotropic. (adjective) Changes in proteins are less likely to underlie such changes because most regulatory proteins are constrained due to their pleiotropic roles in the development of different structures. A Decade Spanning Single Exchange. This may be an important pleiotropic effect whereby rosuvastatin reduces mortality in patients with coronary artery disease. The pleiotropic effect is produced by a gene owing to a cascade (succession) of reactions during some metabolic pathway which is influenced by the original gene product and contributes to different phenotypic effects.
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Different approaches to the study of 2016-09-01 · The pleiotropic effects of the statins improve vascular relaxation, promote new vessel formation, inhibit platelet aggregation and reducing vascular inflammation. It is noteworthy that the pleiotropic properties of the statins have been beneficial in a variety of diseases that involve a number of organs and organ systems. What is pleiotropic?

See also: What is the meaning of Genes, More, Trans, Organism, Gene? Pleated sheet : Meaning of pleiotropy.
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The pleiotropic effect is produced by a gene owing to a cascade (succession) of reactions during some metabolic pathway which is influenced by the original gene product and contributes to different phenotypic effects. The ratio is 2:1 instead of 3:1.

Misspelling of pleiotropic. This is the meaning of pleiotropic: pleiotropic (English) Adjective pleiotropic (comparative more pleiotropic, superlative most pleiotropic) of or pertaining to pleiotropy; Translations pleiotropic - pertaining to pleiotropy.

In pleiotropy, a single gene affects many traits. That means the gene product is used in many types of cells in different tissues. Sometimes, the gene product may act as a signaling molecule, affecting the functions of many tissues. The gene, which is responsible for the coat color of mice is pleiotropic.

25 Oct 2019 By our definition, then, pleiotropy means that one variant shows significant associations across GWASs of multiple traits. We additionally restrict Pleiotropic Effects of Statins and Their. Clinical Significance.

The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. Pleiotropism is a central term in developmental genetics. In pleiotropism, a single gene affects a number of phenotypic traits in the same organism.